Year Surgery Indication Ptns Comments
Dandy
(1928) [1]
AH Right-sided glioma 5 Basal ganglia removal, ligation of MCA and ACA at the carotid bifurcation,
Hemisphere removed in fragments
Gardner (1933) [20] AH Neoplasia 3 Basal ganglia preservation improve motor outcome
McKenzie (1938) [7[ AH Post-traumatic intractrable seizures 1 En-block hemispheric removal
Krynauw (1950) [8] AH Infantile hemiplegia 12 Reduction in seizure frequency, improvement in cognitive and behavioral outcome
Falconer (1960) [11] AH Sturge –Weber Syndrome 5 Reduction in seizure frequency, improvement in behavioral disorders, and worsening in hemiplegia
Oppenheimer and Griffith (1966) [9] AH Infantile hemiplegia 18 Described the SCH concept (16.6%)
Wilson
(1968) [10]
m-AH Infantile hemiplegia 50 SCH management with membrane removal, lavage and shunting, and foramen of Monroe obstruction with a muscle plug
Rasmussen (1983) [12] FH Intractable epilepsy 57 FH protects against SCH at the expense of seizure control
Delalante (1992 and 2007) [14] VPH Intractable epilepsy 83 VPH is a safe and effective disconnection technique for intractable epilepsy in children
Winston (1992) [22] HC Chronic epilepsy 11 HC outcome compares favorably with that of more extensive surgical procedures, yet is associated with significantly less risk
Schramm (1995) [15] HD Intractable epilepsy 13 HD entails a smaller trepanation, less operation time, and less blood loss, it leaves more brain tissue, but with equivalent seizure control as compared with other functional hemispherectomy techniques
Villemure (1995) [13] PIH Intractable epilepsy 11 PIH is a minimally-aggressive tractotomy with few complication
Schramm (2001) [21] TFH Intractable epilepsy 20 Method of choice in cases with enlarged ventricles or perinatal ischemic cysts and is not recommended for hemimegalencephaly
Table 1: Milestones in hemispheric surgery (Ptns: number of patients, AH: anatomical hemispherectomy, SCH: superficial cerebral hemosiderosis, m-AH: modified anatomical hemispherectomy, FH: functional hemispherectomy, VPH: ventral parasagittal hemispherectomy, HC: hemicorticectomy, HD: hemispheric deafferentation, PIH: peri-insular hemispherotomy, TFH: trans-sylvian functional hemispherectomy)