Figure 1: Neuronal pathways, classical neurotransmitters and neuropeptides involved in generalized epilepsy. 5-HT: serotonin; A: adenosine; Ach: acetylcholine; DA: dopamine; GABA: gammaaminobutyric acid; Gal: galanin; Glu: glutamate; NPY: neuropeptide Y. The following subreceptors are indicated: A2AR: A2A receptor, a subreceptor of the adenosine receptor; AMPAR: AMPA receptor, a subreceptor of the ionotropic glutaminergic receptor; GABAAR: GABAA receptor, a subreceptor of the GABA receptor; GABABR: GABAB receptor, a subreceptor of the GABA receptor; 5-HT2CR: 5-HT2C receptor, a subreceptor of the serotoninergic receptor; 5-HT7R: 5-HT7 receptor, a subreceptor of the serotoninergic receptor; D2R: D2 receptor, a subreceptor of the dopaminergic receptor; Gal1R: Gal1 receptor, a subreceptor of the galanin receptor; KAR: kainate receptor, a subreceptor of the ionotropic glutaminergic receptor; m5GluR: m5Glu receptor, a subreceptor of the metabotropic glutaminergic receptor; nAch alpha4beta2R: a subreceptor of the nicotinergic ACh receptor; nAChalpha7R: nAch alpha7 receptor: a subreceptor of the nicotinergic ACh receptor; NMDAR: NMDA (N-methyl-Daspartate) receptor, a subreceptor of the ionotropic glutaminergic receptor; NPY1R: NPY1 receptor, a subreceptor of the neuropeptide Y receptor; NPY2R: NPY2 receptor, a subreceptor of the neuropeptide Y receptor. A plus mark indicates a postsynaptic excitatory impulse; a minus mark indicates a presynaptic inhibitory impulse. ↑: increase; ↓: decrease.