Sample Type of Study Follow-up period Diagnostic criteria for MCI Diagnostic criteria for AD Gironell A, et al 2005 116 controls Nested case-control and cohort 27.7±4 mo Petersen’s criteria DSM-IV and NINCDS-ADRDA Golob EJ, et al 2007 44 elderly controls, 22 adult controls, 41 MCI and 14 AD Prospective cohort 6 yrs Petersen’s criteria NINCDS-ADRDA Papaliagkas V, et al 2008 91 MCI and 30 controls Prospective cohort 23±3 mo Petersen’s criteria DSM-IV Lai CL, et al 2010 20 AD, 18 MCI and 14 controls Prospective cohort 12 mo Petersen’s criteria DSM-IV and NINCDS-ADRDA Papaliagkas VT, et al 2010 20 MCI Prospective cohort 11±5.9 mo Petersen’s criteria DSM-IV Bennys K, et al 2011 71 MCI and 31 controls Prospective cohort 12 mo Petersen’s criteria uninformed Papaliagkas VT, et al 2011 22 MCI and 30 controls Prospective cohort 14±5.2 mo Petersen’s criteria DSM-IV-TR Alzheimer’s dementia: AD; Mild cognitive impairment: MCI; Month: mo; Diagnostic and Statistical Manual of Mental Disorders: DSM; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's disease and Related Disorders Association

Table 1: Methodological aspects of the selected studies.