Reference |
Number of patients |
Underlying Illness |
Antiviral Rx |
Other Rx |
Outcome |
(34) JAMA Neurol 39: 785. |
1 |
Hodgekin’s lymphoma |
None |
Prednisone 65 mg qd Cyclophosphamide (Total duration of all treatment said to be 7 months) |
Improved mental status and seizures, but residual paraplegia |
[4] Ann Neurol 19: 7-14. |
2 |
Hodgekin’s lymphoma and diffuse histiocytic lymphoma |
None |
None |
Both patients died |
[35] Biomed Pharmacother 51: 449-54. |
2 |
HIV infection |
Acyclovir 30 mg/kg qd IV for 1 month |
Corticosteroids for 1 month |
Hemiparesis improved in both; patient with retinal necrosis had persistent loss of vision |
[36]Dermatology 200: 173-175. |
1 |
large B cell lymphoma |
Acyclovir IV 10 mg/kg TID for 7 days |
None |
Improved |
[37] IDSA 35: 330-333. |
1 |
HIV infection |
Acyclovir 10 mg/kg TID IV for 24 days, followed by Valacyclovir 2 GM po TID for 4 weeks |
None |
Improved |
[38] NEJM 347: 1500-1503. |
1 |
chronic lymphocytic leukemia |
Acyclovir 10-15 mg/kg TID IV for 7 days |
None |
Improved |
[39] Pathology 34: 88-93. |
1 |
HIV infection |
Acyclovir IV |
None |
Died |
[19] Neurology 70: 853-60. |
3 |
HIV infection (2 patients) and leukemia (1 patient) |
Acyclovir IV (dose and duration not specified) |
None |
2 improved; 1 died |
[19] Neurology 70: 853-60. |
1 |
HIV infection |
Acyclovir IV (dose and duration not specified) followed by Famvir 500 mg po TID (duration unknown) |
None |
Stabilized |
[19] Neurology 70: 853-60. |
1 |
HIV infection |
Acyclovir IV (dose and duration not specified) followed by Valacyclovir for 4 weeks (dose unknown) |
None |
Improved |
[19] Neurology 70: 853-60. |
3 |
Lymphoma, “low CD4” of unknown etiology, and chronic lymphocytic leukemia |
Acyclovir IV (dose and duration not specified) |
Corticosteroids (po and/or IV) |
2 progressed; 1 improved |
[19] Neurology 70: 853-60. |
3 |
Rheumatoid arthritis and systemic lupus erythematosus (1 patient with both), CREST syndrome, and HIV infection |
Acyclovir IV (dose and duration not specified) |
Later addition of corticosteroids (plus one patient received acetylsalicylic acid) |
2 improved; 1 stabilized after addition of corticosteroids |
[40] Rev Neurol 164: 61-71. |
3 |
Osteosarcoma, heart/lung transplant, and systemic lupus erythematosus |
Acyclovir 30mg/kg qd IV (duration not specified) |
None |
Improved |
[41] CID 48: 372-373. |
1 |
HIV infection |
Acyclovir IV (dose and duration not specified) |
Corticosteroids |
Died |
[42] J Int Assoc Physicians AIDS Care 10: 144-145. |
1 |
HIV infection |
Acyclovir 10 mg/kg TID IV for 10 days |
None |
Improved |