Typical Atypical
Age 15- 45 years old <15; >45 years old
Side Unilateral Bilateral; rapidly sequencial to the fellow eye
Onset Acute; subacute (1-2 weeks) Insidious; Chronic
VA Moderate affectation Severe affectation
Pain with eye movement Present Absent; mild discomfort
Fundus exam Normal (2/3); diffuse edema without hemorrhages (1/3); periphlebitis; resolved within two months Normal; sectorial edema; hemorrhages; persistent after two months
Evolution Spontaneous resolution; steroids  accelerate the recovery of VA Progression after two weeks; steroids unresponsive forms (at least two lines of VA); marked steroids responsive forms
RAPD Present Present
RAPD: Relative Afferent Pupilary Defect. If there is an optic neuropathy of the fellow eye could not be present. VA: Visual Acuity.
Table 2. Differential features between typical and atypical optic neuritis.