| MAOB ( = degrading enzyme of trace amines) |
| 1 . Striatal PEA increase in MAOB knockout mice [37]. |
| 2 . Therapeutic usage of MAOB inhibitor for hypersomnia. |
| (Due to PEA increase?) |
| Neural stem cell (NSC) |
| 1. NSC dysfunction hypothesis of schizophrenia. |
| 2. Findings of ventricular enlargement in brain imaging |
| of schizophrenics. |
| 3. D-neuron decrease in striatum and nucleus accumbens of patients |
| with schizophrenia. |
| Trace amine (TA) |
| 1. Disturbance of sleep-wake-rhythm of patients with |
| schizophrenia. (insomnia and daytime hypersomnia) |
| 2. Decrease of putative trace amine-producing neurons |
| (=D-neurons) in post-mortem brains of schizophrenics. |
| 3. Decreased anxiety-related behaviors in PEA-elevated |
| MAOB knockout mice [38]. |
| 4. “Phenylalanine hypothesis of affective behavior” |
| by Sabelli & Mosnaim (1974) [39] |
| NSC suppression via DA D2 receptors on NSC |
| Preventive effects of chronic administration of |
| D2 blocking agents for recurrent psychoses. |
