Figure 3: COG112 treatment was associated with increased tcMMEP amplitudes following VLF demyelination in vivo. A) The tcMMEP waveforms of vehicle, Antp and COG112 treated mice on day 1 before surgery (-1d) as well as day 3, 7 and 21 after surgery. B & C) LPC-induced demyelination resulted in a decrease in the tcMMEP amplitude to the background noise level and a delay or no response latency at day 3, with spontaneous recovery in tcMMEP beginning at day 7. The tcMMEP amplitude of COG112 group was significantly greater than those of Antp and vehicle control; while the response latency of COG112 group was significantly shorter than those of Antp and vehicle control. *, P< 0.05; **, P< 0.01; ***, P< 0.001 in COG112 group relative to previous time points or vehicle control.