Figure 6: A) Ultrastructure of the spinal cord that compares myelination in mice with and without LPC lesion (sham), and compared to mice with LPC injuries expose to vehicle, Antp and COG112 treatments (Bar = 5 m). At day 21, the number of thinly myelinated axons are greater in COG112 treated mice than Antp and vehicle groups. B) Measuring the myelinated axons with myelin thickness the mean g-ratios of the axons in COG112 group was significantly smaller than vehicle or Antp treated mice indicative of thicker myelin. C) Injection of LPC reduced axon count in lesion area of vehicle and Antp groups while more fibers were preserved in COG112 group, indicating its role in axon preservation following the injury. (mean ± SEM, * p< 0.05, ** p < 0.01, ***, p< 0.001, n = 3).