Medication Combination MPR, % P Value vs Brimonidine/Timolol
Brimonidine/timolol (n=1242) 42.7
Dorzolamide/timolol (n=2868) 40.6 0.0208
β-blocker+brimonidine (n=365) 23.3 <0.0001
β-blocker+CAI (n=236) 25.0 <0.0001
β-blocker+PGA (n=1025) 25.4 <0.0001
CAI+brimonidine (n=329) 26.3 <0.0001
CAI+PGA (n=618) 34.9 <0.0001
PGA+brimonidine (n=1200) 32.2 <0.0001
CAI: Carbonic Anhydrase Inhibitor; MPR: Medication Possession Ratio; PGA: Prostaglandin Analogue
Table 2: MPRs for fixed-combination brimonidine/timolol versus fixed-combination dorzolamide/timolol or various two-bottle combinations of topical glaucoma therapy for up to 12 months following the index prescription.