| Age [mean ± SD] |
77 ± 8 years |
| Visual acuity [mean ± SD] |
|
| Baseline (n=72) |
0.53 ± 0.31 logMAR |
| After 3 injections (n=72) |
0.44 ± 0.33 logMAR |
| 12 months follow-up (n=33) |
0.45 ± 0.32 logMAR |
| 24 months follow-up (n=26) |
0.55 ± 0.43 logMAR |
| 36 months follow-up (n=22) |
0.62 ± 0.47 logMAR |
| Number of injections since baseline [mean ± SD] |
|
| 12 months follow-up (n=33) |
6.2 ± 1.6 |
| 24 months follow-up (n=26) |
10.4 ± 3.0 |
| 36 months follow-up (n=22) |
16.1 ± 4.8 |
| CNV activity after 3 injections [n (%)] |
27 (37.5%) |
|
Type of choroidal neovascularization [n (%)] |
|
| Predominantly classic lesion |
15 (20.8 %) |
| Minimally classic lesion |
7 (9.7 %) |
| Occult with no classic lesion |
50 (69.4 %) |
|
without RAP |
35 (70 %) |
|
with RAP |
15 (30 %) |
|
Presence of SDOCT parameters at baseline [n (%)] |
|
| Pigment epithelial detachment |
67 (93.1%) |
| Subretinal fluid |
67 (93.1%) |
| Cystoid spaces |
36 (50.0%) |
|
Size of CNV lesion components on FA at baseline [area, mean±SD] |
|
| Total CNV lesion |
5.49 ± 5.78 mm2 |
| Occult CNV lesion component |
4.78 ± 5.22 mm2 |
| Classic CNV lesion component |
0.29 ± 0.67 mm2 |
|
Volume of SDOCT parameters at baseline [mean ± SD] |
| Neurosensory retina |
FCS |
0.23 ± 0.08 mm3 |
| Outer nuclear layer |
FCS |
0.09 ± 0.03 mm3 |
| Subretinal fluid |
FCS |
0.04 ± 0.06 mm3 |
| |
Total volume |
0.40 ± 0.60 mm3 |
| |
Area |
4.95 ± 5.06 mm2 |
| Subretinal hyperreflective material |
FCS |
0.02 ± 0.04 mm3 |
| |
Total volume |
0.14 ± 0.30 mm3 |
| |
Area |
1.85 ± 2.76 mm2 |
| Pigment epithelial detachment |
FCS |
0.07 ± 0.10 mm3 |
| |
Total volume |
0.73 ± 1.28 mm3 |
| |
Area |
6.94 ± 5.88 mm2 |
LogMAR: Logarithm of the Minimum Angle of Resolution; SD: Standard Deviation;
SDOCT: Spectral Domain Optical Coherence Tomography; CNV: Choroidal
Neovascularisation; FA: Fluorescein Angiography; RAP: Retinal Angiomatous
Proliferation; FCS: Foveal Central Subfield