Figure 5: Expression of gp130 in the ganglion cell and nerve fiber layers is dependent upon eccentricity and increases with normal aging. Quantification of immunolabeling in the ganglion cell and nerve fiber layers of central (A) and peripheral (B) regions of retina in whole eye paraffin sections from young C57, aged C57, young DBA/2 and aged DBA/2 mice. Data is plotted as intensity of gp130 immunolabeling in arbitrary units and asterisks indicate statistical significance (p < 0.05). Glaucoma-related stressors do not alter the intensity of gp130 immunolabeling in central retina (A). The intensity of gp130 labeling is greater in peripheral retina than in central retina for all groups (B compare to A). In peripheral retina, labeling intensity of gp130 is greater in aged C57 retina than that in young C57 and DBA/2 retina (B).