Figure 1

GCL: Ganglion Cell Layer; IPL: Inner Plexiform Layer; INL: Inner Nuclear Layer; OPL: Outer Plexiform Layer; ONL: Outer Nuclear Layer; IS: Inner Segment; OS: Outer Segment; RPE: Retinal Pigmented Epithelium (hematoxylin & eosin, original magnification x200)

Figure 1: Photomicrograph of DKO^rd8 and DKO retinas. (A) DKO without Crb1^rd8 background does not show photoreceptor shortening in the IS/OS. The RPE is unremarkable. (B) DKO^rd8 shows RPE degeneration (black arrow), shortening of the IS/OS and photoreceptor degeneration (white arrow), and rd8-associated lesions (asterisks).