Figure 4: Self Controls. In self control experiments, DKOrd8 mice are treated intraocularly with a therapeutic agent in one eye (in blue) while the other (contralateral) eye (in red) is treated with control agent (placebo) or left untreated. Mice are followed by fundoscopy for certain duration (usually 2-3 months), then sacrificed, and the retinal samples are analyzed for a variety of AMD biomarkers and histology. Inset: Magnified schematic of intravitreal injection. Treatment or placebo are injected into the vitreous humor of the mouse eye where it can diffuse to the retina.