Group 1 Epithelium-Off A-CXL Group 2 Epithelium-Off A-CXL Group 3 Epithelium-Off A-CXL Group 4 Epithelium-On A-CXL 5 eyes 5 eyes 5 eyes 5 eyes 16-23 13-26 14-24 21-26 Riboflavin 0.1% plus Dextran 20% (VibeX) Riboflavin 0.1% plus Dextran 20% (VibeX) Riboflavin 0.1% plus HPMC (VibeX Rapid) Riboflavin 0.25% plus EDTA, BAK, TRIS (Paracel) 15 minutes 20 minutes 10 minutes 10 minutes 12 mW/cm2 30 mW/cm2 30 mW/cm2 45 mW/cm2 10 min 4 min 4 min 2 min. and 40 sec 7.2 J/cm2 7.2 J/cm2 7.2 J/cm2 7.2 J/cm2 180 µm (range 160-200 µm) 160 µm (range 150-180 µm) 155 µm (range 140-180 µm) 80 µm (range 50-120 µm) 180 µm (range 150-200 µm) 160 µm (range 150-180 µm) 150 µm (range 140-180 µm) noevidentdemarcation line

Table 1: Overview of treatment parameters and respective results according to demarcation lines measurements after in vivo scanning laser confocal microscopy and corneal OCT.