Figure 5: Prevention of acellular capillary by anti-TNFα treatment. The STZ-induced diabetic mice were IP injected antibody weekly for 6 months. (A-E) The example images of isolated retinal vasculatures for non-diabetic mice (A), PBS (B), the antibody doses of 2 mg/kg (C), 8 mg/kg (D), and 25 mg/kg (E). Arrows indicated acellular capillaries. (F) Quantitative results. The results were the averaged acellular capillary/mm2 retina (n=6). *p<0.05 compared to non-diabetes. #p<0.05 compared to diabetes with PBS treatment. Scale bar: 50 μm.