| Author |
n= |
Study Type |
Location |
Reported Outcome |
| Setlik et al. [10] |
Perforated cornea
(n=22)
(Isobutyl-cyanoacrylate) |
Retrospective case series |
USA |
40.9% healed with adhesive alone.
31.8% needed PK.
27.3% multiple application. |
| Garg et al.[11] |
Perforated fungal keratitis
(n=66)
(Butyl-cyanoacrylate) |
Retrospective case series |
India |
63.6% infiltrate resolved with scar formation.
37.8% multiple application.
24.2% worsening keratitis.
12.1% successful PK. |
| Moorthy et al. [12] |
Perforated herpetic keratitis
(n=46)
(Butyl- cyanoacrylate) |
Retrospective case series |
Australia |
57% needed PK.
37% complete healing.
31% multiple application.
4% evisceration. |
| Kasetsuwan et al. [15] |
Impending and perforated corneas
(n=66)
(Ethyl- cyanoacrylate) |
Retrospective case series |
Thailand |
91% successful.
26% required definitive treatment. |
| Tan et al. [17]
(this study) |
Mixed Aetiologies of perforated cornea
N=45
(Butyl-cyanoacrylate) |
Retrospective case series |
Australia |
67% successful as definitive and temporising measure.
47% healed with adhesive alone. |
| Sharma et al. [18] |
Fibrin (n=19)
Cyanoacrylate
(n = 22)
(Butyl- cyanoacrylate) |
Randomised controlled
clinical trial |
India |
Both effective.
Fibrin glue healed faster. Fibrin glue induced less cornea vascularisation. Fibrin glue required longer time for adhesive plug formation. |
| Okabe et al. [19] |
Corneal (n=2)
Bleb leak (n=2)
(Octyl-cyanoacrylate) |
Case series |
Japan |
All effective.
Several applications required.
No adverse clinical effects. |
