| |
[31] |
[23] |
[17] |
[32] |
[33] |
[34] |
| Type of experimental myopia |
Negative lenses or light diffusers |
Goggled eyes |
Monocularly deprived by placement of a translucent occluder over the left eye |
Lids were surgically fused at birth and kept closed for one year |
Lens-induced myopia and form-deprivation myopia |
Translucent goggles |
| Animals |
Chickens |
Leghorn cockerels |
Chicks |
Macaque monkeys |
Chicks |
Chicks |
| Methods |
Intravitreal injections of atropine daily for 4 days, starting at day 8 post-hatching. Finally, atropine was intraperitoneally injected for 4 days in chicks that wore monocularly -7D lenses. |
Various concentrations of different substantions, among them-atropine, were injected into goggled eyes three times at 48-hour intervals. Fellow control eyes received saline. Control animals received saline in both eyes. |
A series of intravitreal injections of atropine (n=8) or saline vehicle (n=8) |
Arctoides atropine administration |
10-microL intravitreal injections in combination of Apomorphine alone or given with atropine. |
Atropine solution was injected into the vitreous at two-day intervals. |
| Results |
Intraperitoneal injection inhibited myopia development only at the highest dose. This inhibition was still less when the same dose was provided through the vitreous of the fellow eye. |
Other than atropine and pirenzepine, only oxyphenonium caused full rescue from myopia. |
Significant reduction in experimentally induced myopia in atropine-injected chicks, associated with a marked reduction in the axial elongation of the deprived eye. |
In Macacaarctoides, atropine administration prevents abnormal eye elongation, and this suggests that lid-fusion myopia is caused by excessive accommodation. |
Cholinergic mechanisms are indicated by the inhibitory effects of atropine on both lens-induced myopia and form-deprivation myopia. |
Atropine suppressed myopia only at doses at which severe nonspecific side effects were observed in the retina. |
| UK: Unknow; D: Diopter |
