Reference Imaging               Size of mass Positive Immunohistochemistry Negative Immunohistochemistry
[3] Irregular, nodular mass with lateral rectus involvement 4×2×1.5 cm Keratin, B-72.3 HMB-45, NSE, S-100, CEA, PSA, Chromogrannin
[4] Nodular, cystic mass compressing the optic nerve and eyeball 2.5×1.3×1 cm EMA, CEA, Cytokeratin positive S-100 focally positive Actin, estrogen receptor, Prostate specific antigen
[5] Ill-defined large mass with homogenous enhancement with bony remodeling NA NA PhosphoTungestic Acid Hematoxyline (PTAH)
[6] Ill-defined mass with diffuse enhancement 1.5×1×.3 cm Cytokeratin-7, CEA, EMA, BRST-2, AE-1 PSA, Her-2/neu, p-53, estrogen receptor, S-100
[7] Ill-defined mass with intralesional calcification present with bony erosion 3 cm Cytokeratin-7, 18, 19, 34β E 12 Positive, Cytokeratin-10, 17 partially positive S-100, Cytokeratin-20, α-smooth muscle actin
[8] NA NA NA NA
[9] Homogenously enhancing, well defined, large ovoid mass in superolateral orbit 4×2.5×2 cm Cytokeratin-7, 19, EMA Cytokeratin- 20, estrogen receptor, progesterone receptor, C-erb-B2, S-100, α smooth muscle actin
[10] Infiltrative mass with ill-defined margins with lateral rectus involvement 2.4×1.5×1 cm Cytokeratin-7, MMP-2,9, 13, Her-2/neu Cytokeratin-5, 20, p-53, prostate specific antigen, S-100, TTF
[11] Irregular mass with bone destruction 2.8 cm Androgen receptor, Her-2/neu, p53, Ki-67 Estrogen receptor, progesterone receptor
Ill-defined mass with extension along superior rectus, calcification present 4 cm Androgen receptor, p53, Ki-67 Estrogen receptor, progesterone receptor, Her-2/neu
Diffuse irregular mass 3.7 cm Androgen receptor, p53, Ki-67 Estrogen receptor, progesterone receptor, Her-2/neu
Diffuse mass with bone destruction, calcification present 2.5 cm Androgen receptor, p53, Ki-67, Her-2/neu Estrogen receptor, progesterone receptor
Irregular mass, calcification present 2.5 cm Androgen receptor, p53, Ki-67, Her-2/neu Estrogen receptor, progesterone receptor
Our case Ill-defined mass with erosion of the orbital roof 3.5×2.5×2.5 cm Cytokeratin-7, 10. Epithelial membrane antigen S-100, Cytokeratin-20, Her-2/neu, p53, estrogen receptor
Table 2: Imaging and immunohistochemical features of the published cases of primary ductal adenocarcinoma of the lacrimal gland.