exam 1 vs 2 beg vs adv Progr vs non progr MD ns p<0.001 ns IOP ns p<0.001 ns Number p<0.001 p<0.05 ns Symmetry ns ns ns Superior ratio p<0.005 p<0.02 ns Inferior ratio ns p<0.001 ns Superior/nasal ns ns ns Maximal modulation ns p<0.005 ns Ellipse modulation ns p<0.001 p<0.05 Average thickness p<0.005 ns ns Ellipse average p<0.001 ns ns Superior average p<0.001 ns ns Inferior average ns ns ns Superior integral p<0.001 ns ns Average diameter ns p<0.001 ns Effective area ns p<0.05 ns Cupping shape p<0.001 ns p<0.05 Volume below ns ns ns Average depth p<0.05 ns p<0.02 Mean contour depth p<0.05 ns p<0.02 Volume above ns ns ns NRR area ns ns ns CDR ns ns ns Horiz. CDR ns ns p<0.05 Vert. CDR ns ns ns

Table 2: Differences (level of significance) of the various parameters between a) first and second examination (time), b) beginning and advanced disease, c) progressive and non-progressive disease.