Ref. Author, year Method Sample Outcome
38 Vestergaard AH et al. 2014 Prospective, randomized, single-masked clinical trial. Included patients treated for moderate to high myopia with FLEX in one eye and SMILE in the other 35 patients, 70 eyes No significant differences between FLEX and SMILE at 6 months in terms of pachymetry, CH and CRF
39 Agca A et al. 2014 Prospective comparative case series. One eye of each patient was treated with SMILE, and the fellow eye with femto-LASIK 30 patients, 60 eyes No differences between femto-LASIK and SMILE treatments at 6 months in terms of postoperative CH or CRF.
40 Penderson IB et al. 2014 Retrospective evaluation of corneal biomechanical properties after LASIK, ReLEx flex, and ReLEx SMILE using Corvis ST and ORA on patients treated for high myopia (-10.5 to -5.5 diopters) more than one year previously  LASIK (35 eyes), ReLEx flex (31 eyes), and ReLEx smile (29 eyes). A control group included 31 healthy eyes LASIK and ReLEx flex and the flap-free ReLEx smile result in similar reduction in corneal biomechanics when evaluated by Corvis ST and ORA.
41 Shen Y et al. 2014 Retrospective study measuring corneal deformation parameters using CorVis ST between groups 17 eyes of 17 patients after SMILE, 18 eyes of 18 patients after LASEK17 eyes of 17 patients after femtosecond LASIK   No significant difference in deformation amplitude and applanation time (applanation 1) between the LASEK and SMILE groups nor between the SMILE and femtosecond-LASIK groups. 3 months after surgery
42 Wang D et al. 2014 Prospective study. Patients grouped according to SMILE or LASIK and -6.00 diopters (D) or less (> -6.00 D) or myopia greater than -6.00 D (>-6.00 D). CH, CRF, and 37 waveform parameters were recorded using ORA and compared preoperatively and at 1 week and 1 and 3 months postoperatively. 187 eyes had SMILE, 79 eyes had LASIK In myopia greater than -6.00 D, the CH, CRF, p1area, and p2area decreased significantly more in LASIK than in SMILE 
43 Wu D et al. 2014 Prospective comparative case series. Patients had SMILE or femtosecond LASIK. CH, CRF and 37 other biomechanical waveform parameters were quantitatively assessed with the Ocular Response Analyzer preoperatively and 1 week and , 3, and 6 months postoperatively. 40 eyes had SMILE, 40 eyes had femtosecond LASIK CH and CRF values in the SMILE Group were significantly higher than those in the femtosecond LASIK group 3 months and 6 months postoperatively
Table 1: Summary of recent papers comparing biomechanical outcomes of LASIK techniques versus SMILE.