Ref #

Case #

NSAID Drops Indicated Post..

Days of Use

Complications

Medical History

Age

1

1

Surgery

10

Scleral melt, conjuctival defect, culture negative

None reported

77

1

2

Surgery

18

Corneal melt at wound, ulceration at sideport, culture negative

Diabetes, coronary heart disease

86

1

3

Surgery

30

Scleral melt, culture negative

None reported

82

1

4

Surgery

105

Corneal melt at cataract wound

Diabetes, rheumatoid arthritis

70

1

5

Not reported

19

Central corneal melt both eyes

Diabetes, sarcoidosis

43

1

6

Surgery

21

Corneal melt, ulceration and infiltrate, culture negative

None reported

67

2

7

Surgery

15

Corneal melt with infiltrate, ulceration, 80% thinning

None reported

58

2

8

Surgery

40

Corneal melt with 60% thinning

None reported

71

2

9

Surgery

5

Corneal melt with perforation

Anemia

76

3

10

Surgery

10

Corneal melt, 80% thinning, eventual perforation

Coronary heart disease, hypertension, hyperlipidemia, hiatal hernia

76

3

11

Cataract Surgery

29

Corneal melt with 50% thinning

Hypothyroid

66

3

12

Cataract Surgery

18

Corneal melt with perforation

Arrhythmia

77

3

13

Cataract Surgery

11

Corneal melt, 90% thinning, eventual perforation

Coronary heart disease, hypertension, diabetes, gastritis

71

3

14

Surgery

17

Corneal melt, 99% thinning, eventual perforation

Hypothyroid

79

4

15

Surgery

10

Corneal ulcer with melt, 80% thinning, eventual perforation

None reported

76

4

16

Cataract surgery

29

Corneal melt with 50% thinning

None reported

66

4

17

Cataract surgery

18

Corneal melt with perforation

None reported

77

4

18

Cataract surgery

11

Corneal melt with perforation

Diabetes, hypertension

71

4

19

Surgery

17

Corneal melt with descmetocele

None reported

79

4

20

Surgery

5

Corneal melt with perforation

None reported

27

4

21

Surgery

4

Corneal melt with descmetocele

None reported

47

4

22

Surgery

300 (drug1), 120 (drug2)

Corneal melt with descmetocele

None reported

80

4

23

Surgery

150

Corneal melt with descmetocele

None reported

65

4

24

Surgery

14

Corneal melt with eventual perforation

None reported

77

5

25

PRK

5

Corneal melt with perforation

None reported, including negative serologies

31

6

26

Surgery

10

Corneal melt with central perforation

Hypertension

79

7

27

Surgery

14

Corneal melt

None reported

62

8

28

Surgery

14

Central corneal melt with perforation

Graft vs host disease, post allogeneic stem cell transplant for leukemia

56

9

29

Surgery

60

Central corneal melt with perforation, cultures negative

None reported

50

10

30

PRK

5

Corneal melt with perforation, cultures negative

None reported

27

10

31

PRK

3

Central corneal melt with descmetocele

None reported

49

10

32

Surgery

300

Central corneal melt with descmetocele, eventual perforation

Diabetes

80

11

33

LASIK

6

Dislodged flap, corneal melt, descmetocele, ring infiltrate

None reported

42

11

34

LASIK

3

Dislodged flap, corneal melt, descmetocele, ring infiltrate

Leukemia, status post bone marrow transplant

41

11

35

Surgery

14

Dislodged flap, corneal melt perforation, descmetocele, ring infiltrate

None reported

44

12

36

Cataract surgery

21

Melt with perforation

None reported

83

13

37

Vitrectomy

25

Melts

Asthma, gastroesophageal reflux, prematurity

38

13

38

Vitrectomy

25

Melts

None reported

77

Table 1: Synopsis of published and reported cases.