Traditional anaesthetic agents: Type Onset Potency Toxicity Duration
Procaine 2-chloroprocaine Tetracaine (Amethocaine) Cocaine Ester Ester Ester Ester Slow Rapid Slow Slow

Low Intermediate Intermediate

High

Low Low Intermediate Very High Short Short Intermediate Long
Benoxinate (oxybuprocaine) Ester It must be used in lowest possible dosa ge [36] to avoid: i) lethal reactions in low cholinesterase activities ii) allergy to the para-aminobenzoic moities iii) absorption through nasal-lacrimal apparatus or mucous membrane
Bupivacaine Lidocaine Ropivacaine Etidocaine Amide Amide Amide Amide Slow Rapid Slow Rapid High Intermediate Intermediate High High Low Intermediate High Long Short Long Long
Newly developed anaesthetic agents
Articaine Levobupivacaine 2-Choloroprocaine Proxymethacaine Amide Amide Ester Ester Rapid Slow Rapid Rapid   Low High Low Low Long Long Short Intermediate
Table 1: Properties of popular local anaesthetics used for ocular surgery [38,40,46,47].