Traditional
anaesthetic
agents: |
Type |
Onset |
Potency |
Toxicity |
Duration |
Procaine
2-chloroprocaine
Tetracaine
(Amethocaine)
Cocaine |
Ester
Ester
Ester
Ester |
Slow
Rapid
Slow
Slow |
Low
Intermediate
Intermediate
High |
Low
Low
Intermediate
Very High |
Short
Short
Intermediate
Long |
Benoxinate
(oxybuprocaine) |
Ester |
It must be used in lowest possible dosa
ge [36] to avoid:
i) lethal reactions in low cholinesterase activities
ii) allergy to the para-aminobenzoic moities
iii) absorption through nasal-lacrimal apparatus or mucous membrane |
Bupivacaine
Lidocaine
Ropivacaine
Etidocaine |
Amide Amide
Amide
Amide |
Slow
Rapid
Slow
Rapid |
High
Intermediate
Intermediate
High |
High
Low
Intermediate
High |
Long
Short
Long
Long |
Newly developed
anaesthetic
agents |
Articaine
Levobupivacaine
2-Choloroprocaine
Proxymethacaine |
Amide Amide
Ester Ester |
Rapid Slow
Rapid Rapid |
|
Low
High
Low
Low |
Long
Long
Short
Intermediate |