| Amino acid |
|
Treatment |
|
|
Significance |
|
| Liver (nmol/mg wet tissue) |
ROW |
SOY |
SER |
ROW vs SOY |
ROW vs SER |
SOY vs SER |
| D-Serine |
0.00383 ± 0.00031 |
0.00975 ± 0.00069 |
0.0223 ± 0.0068 |
N.S. |
p < 0.05 |
p = 0.09 |
| D-Aspartate |
0.0176 ± 0.0024 |
0.0347 ± 0.0033 |
0.0181 ± 0.0020 |
p < 0.005 |
N.S. |
p < 0.005 |
| L-Aspartate |
0.148 ± 0.015 |
0.265 ± 0.039 |
0.167 ± 0.015 |
p < 0.05 |
N.S. |
p = 0.08 |
| L-Valine |
0.246 ± 0.007 |
0.437 ± 0.038 |
0.255 ± 0.011 |
p < 0.005 |
N.S. |
p < 0.005 |
| L-Leucine |
0.479 ± 0.017 |
0.616 ± 0.043 |
0.516 ± 0.016 |
p < 0.05 |
N.S. |
p = 0.09 |
| L-Isoleucine |
0.104 ± 0.002 |
0.148 ± 0.010 |
0.113 ± 0.005 |
p < 0.01 |
N.S. |
p < 0.05 |
| L-Tyrosine |
0.104 ± 0.002 |
0.148 ± 0.010 |
0.113 ± 0.005 |
p < 0.01 |
N.S. |
p < 0.05 |
| Serum (mM) |
|
|
|
|
|
|
| L-Serine |
0.101 ± 0.004 |
0.226 ± 0.026 |
0.781 ± 0.477 |
N.S. |
N.S. |
N.S. |
| L-Glutamate |
0.128 ± 0.021 |
0.198 ± 0.024 |
0.155 ± 0.020 |
p = 0.11 |
N.S. |
N.S. |
| L-Glutamine |
2.654 ± 0.122 |
4.267 ± 0.656 |
2.752 ± 0.226 |
p = 0.09 |
N.S. |
p = 0.09 |
| L-Aspartate |
0.0252 ± 0.0081 |
0.0641 ± 0.0119 |
0.0403 ± 0.0103 |
p = 0.07 |
N.S. |
N.S. |
| L-Valine |
0.132 ± 0.010 |
0.412 ± 0.060 |
0.135 ± 0.011 |
p < 0.005 |
N.S. |
p < 0.005 |
| L-Leucine |
0.161 ± 0.011 |
0.398 ± 0.064 |
0.178 ± 0.023 |
p < 0.05 |
N.S. |
p < 0.05 |
| L-Isoleucine |
0.0513 ± 0.0040 |
0.137 ± 0.023 |
0.0583 ± 0.0052 |
p < 0.01 |
N.S. |
p < 0.05 |
| L-Arginine |
0.0921± 0.0106 |
0.211 ± 0.039 |
0.127 ± 0.020 |
p < 0.05 |
N.S. |
N.S. |
| L-Histidine |
0.0498 ± 0.0018 |
0.0789 ± 0.0063 |
0.0553 ± 0.0031 |
p < 0.005 |
N.S. |
p < 0.01 |
| L-Phenylalanine |
0.0829 ± 0.0056 |
0.141 ± 0.020 |
0.0984 ± 0.0058 |
p < 0.05 |
N.S. |
N.S. |
| L-Tyrosine |
0.0638 ± 0.0068 |
0.182 ± 0.036 |
0.0776 ± 0.0040 |
p < 0.05 |
N.S. |
p < 0.05 |
Abbreviations: ROW, water filtered by reverse osmotic membrane (control); SER, L-serine; SOY, soy peptides; SDDM, genetic serine-deficiency disease model; N.S.,
not significant. Values are means ± standard errors (n = 4 for ROW group, n = 6 for SOY group, n = 5 for SER group). Amio acid contents in the liver are shown in
nmol/mg wet tissue. Amio acid concentrations in serum are shown in mM. |
