Figure 3:Genistein-stimulated SREBP-2 processing. HepG2 cells were stimulated with genistein for the indicated period of times and analyzed by Western blot. Formation of nuclear SREBP-2 over time after genistein treatment (A), the effects of AEBSF (B) or brefeldin A (C) on the formation of nuclear SREBP-2 by genistein. Protein levels of Insig-1 over the course of genistein treatment for 24 h (D).