| Groups |
GSH
mM/g protein) ) |
SOD |
GPx |
CAT |
| Normal (1 ml saline) |
42.61 ± 4.11 |
1.82 ± 0.24 |
2.15 ± 0.21 |
55.20 ± 3.25 |
| Control (ISO, 85 mg/kg) |
23.74 ± 6.09* |
0.93 ± 0.17* |
0.76 ± 0.33* |
17.75 ± 2.54* |
| Astaxanthin (50 mg/kg) + ISO (85 mg/kg) |
31.85 ± 5.22@ |
1.24 ± 0.35@ |
1.35 ± 0.53@ |
39.45 ± 3.94@ |
| Astaxanthin (100 mg/kg) + ISO (85 mg/kg) |
39.14 ± 4.84* |
1.64 ± 0.45* |
1.80 ± 0.42* |
48.18 ± 6.08* |
| Vitamin C (1 g/kg,b.w) + ISO (85 mg/kg) |
35.25 ± 3.77@ |
1.43 ± 0.26@ |
1.63 ± 0.37@ |
40.22 ± 5.16* |
Isoproterenol was given subcutaneously as a single dose of 85 mg/kg.b.w. to 18 h fasted animals. It was given to all groups except the normal one. astaxanthin (50 and
100 mg/kg) were orally given daily for 58 days and the last dose of each was given 1 h before Isoproterenol administration. Activity is expressed as: 50% of inhibition of
epinephrine autooxidation per min for SOD; μmoles of hydrogen peroxide decomposed per min per mg of protein for catalase; μmoles of glutathione oxidized per min per
mg of protein for GPx. Values are given as mean ± SD for groups of eight animals each.
* Significantly different from normal group at p<0.01. @ Significantly different from control group at p<0.05. |
