Study Psarticipants Intervention (dose per day) Control Study design (Jadad score) Duration Outcome
(Country)
Agerholm-Larsen et al. [37] (Denmark) 70 overweight/obese participants (18-55 y), ♀ (50) and ♂ (20) 1. Two strains of S. thermophilus and two strains of L. acidophilus (4.5 × 1010 CFU and 9 × 109 CFU) 450 mL yoghurt fermented with 2. Delta-acid-lactone (chemically fermented placebo group) And 5. Two placebo pills Double-blind RCT (3) 8 wk ↔BW, FM and waist-to-hip ratio
2. Delta-acid-lactone (chemically acidified placebo)
3. Two strains of S. thermophilus and one strain of L. rhamnosus (3.6 × 1011 CFU and 9 × 1010 CFU)
4. One strain of E. faecium and two strains of S. thermophilus (2.7 × 1010 CFU and 4.5 × 1011 CFU) In 450 mL yoghurt
5: Two placebo pills
Kadooka et al. [38] (Japan) 87 participants with high BMI and visceral abdominal fat areas (33-63 y), ♀ (28) and ♂ (59) L. gasseri SBT2055 (1 × 1011 CFU) In fermented milk 200 g fermented milk Double-blind RCT (3) 12 wk ↓Abdominal visceral, subcutaneous and total fat areas
↓BW, BMI, waist circumference, hip circumference, waist-to-hip ratio, FM and fat percentage
↔Lean mass
Kadooka et al. [39] (Japan) 210 participants with large visceral fat areas (35-60 y), ♀ (105) and ♂(105) 1.L. gasseri SBT2055 (2 × 109 CFU) 200 g fermented milk Double-blind RCT (3) 12 wk 1. and 2. ↓Visceral abdominal fat area, BMI, waist circumference, hip circumference and FM
2.L. gasseri SBT2055 (2 × 108 CFU) ↔Lean mass and subcutaneous fat area
3.Placebo In 200 g fermented milk
Omar et al. [40] (Canada) 28 overweight participants (46.3±2.4 y), ♀ (18) and ♂ (10) 1.L. amylovorus (1.39 × 109 CFU) 100 g fermented yoghurt With diets of 35 E% fat, 50 E% carbohydrate, 15 E% protein Randomized double-blind cross-over (3) 3 × 43 d with 6 wk wash-out ↔FM, BW and lean mass
2.L. fermentum (1.08 × 109 CFU)
3. Placebo In 100 g fermented yoghurt With diets of 35 E% fat, 50 E% carbohydrate and 15 E% protein
Jung et al. [41] (Korea) 57 obese participants, (19-60 y), ♀ (35) and ♂ (22) L. gasseri BNR17 (1 × 1010 CFU) In capsules Placebo capsules Double-blind RCT (3) 12 wk ↔BW, BMI, fat percentage, muscle mass, waist circumference, hip circumference, VAT, SAT and DAT
Sharafedtinov et al. [42] (Russia) 40 obese participants with hypertension, 30-69 y, ♀ (27) and ♂(13) L. plantarum TENSIA DSM 21380 (2.5 × 1010 CFU) In 50 g cheese With LCD 50 g cheese With LCD Double-blind RCT (5) 3 wk ↓BMI
↔BW, muscle mass, and FM
↑Waist-to-hip ratio
Lee et al. [43] (Korea) 50 participants with higher BMI (>25 kg/m2) and waist circumference (>85 cm), 19-65 y, ♀ (64) and ♂ (0) S. thermophiles KCTC 11870BP, L. plantarum KCTC 10782BP, L. acidophilus KCTC11906BP, L. rhamnosus KCTC 12202BP, B. lactis KCTC 11904BP, B. longum KCTC 12200BP, and B. breve KCTC 12201BP (1 × 109 viable cells) In capsules With 3 g Bofutsushosan and hypocaloric diet Placebo capsules With 3 g Bofutsushosan and hypocaloric diet Double-blind RCT (3) 8 wk ↔BW, BMI, waist circumference, fat percentage and FM
Abbreviations: ♀: Women; ♂: Men; B.: Bifidobacterium; BMI: Body Mass Index; BW: Body Weight; CFU: Colony Forming Units; d: Days; DAT: Deep Adipose Tissue; E.: Enterococcus; FM: Fat Mass; g: Gram; L: Lactobacillus; LCD: Low-Calorie Diet; RCT: Randomized Controlled Trial; S: Streptococcus, SAT: Superficial Adipose Tissue; VAT: Visceral Adipose Tissue; wk: Weeks; y: Years.
Table 1: Characteristics of the studies reviewed.