Groups Catalse (CAT) (U/g protein) Glutathione Peroxidase (GPx) (U/g protein) Superoxide Peroxidase (SOD) (U/g protein)  Tissues MDA (nmol/g protein) Control Negative (G1) 66.978±3.296g 91.244±3.62e 910.06±18.66de 77.081±2.412g Control Positive (G2) 10.325±0.934a 48.174±1.787a 503.69±10.92a 127.20±1.714a Gentamicin+ OLE 20 mg/Kg (G3) 31.615±1.914b 63.901±2.105b 753.12±14.41b 107.25±4.676b Gentamicin+ OLE 40 mg/Kg  (G4) 43.725±1.439cd 72.898±1.355d 843.93±33.84c 94.395±2.093cd Gentamicin+ OLE 80 mg/Kg  (G5) 46.132±2.439de 71.153±2.136cd 840.15±11.91c 85.948±1.76ef Gentamicin+ OLE 160 mg/Kg  (G6) 38.599±1.358c 65.125±2.57bc 886.84±8.62cd 99.622±0.694c Gentamicin+ Vit. E (G7) 41.483±1.524cd 73.541±1.51d 853.24±5.56c 95.513±2.69c Gentamicine+ OLE 20 mg/Kg + Vit. E (G8) 50.147±1.275e 88.036±1.109e 917.17±4.58de 87.811±2.114de Gentamicine+ OLE 40 mg/Kg + Vit. E (G9) 59.326±1.87f 87.804±1.962e 955.46±8.26e 80.048±1.45fg

Table 2: Effect of olive leaf extracts, vitamin E, and their combination on renal CAT, GPx, SOD activities and MDA in gentamicin induced nephrotoxic rats. Values represented as Mean ± SE, The mean difference is significant (P < 0.05) when compared with the positive control group (gentamicin-induced nephrotoxicity).