Figure 4: A photomicrograph of sections of pancreatic tissue (A) for a diabetic rat received (Nano 50) shows restoration of the normal size and shape of island of Langerhan but with mild vacuolar degeneration of some cells. (B) For a diabetic rat received (Nano 100) shows atrophy of island of Langerhan. (C) For a diabetic rat received (Nano 150) shows normal size of island of Langerhan with vacuolar degeneration of some cells (arrowhead) and at the periphery of the island. (D) For a diabetic rat received insulin shows atrophy of the island of Langerhan but with no signs of vacuolar degeneration. (Hx. & E. X 200).