aberrations in rat bone

Treat	Structural aberrations							Numerical aberrations
Treat	chromatid gap	Chromoso mal gaps	Chromatid break	Fragment	Deletion	Endo- mitosis	Total aberrations	N-1	N+1	Polyploidy	Total aberrations
Control	0.8±0.20^a	0±0.00^a	0±0.00^a	0.2±0.20^a	0±0.00^a	0±0.00^a	1±0.31^a	0.2±0.20^a	0±0.00^a	0.2±0.20^a	0.4±0.40^a
STZ	5.8±0.37^e	5.4±0.67^e	7.6±0.50^f	5.8±0.37^d	7.2±0.58^e	2.4±0.4	D4.20±0.73	6.4±0.50^g	3.8±0.37^d	3.4±0.24^d	13.6±0.50^h
STZ + insulin	3.8±0.58^C	3.2±0.2^C	3.8±0.2	2±0.00^b	3.4±0.67^C	2±0.00^C	18.2±0.66^e	3.2±0.37^d	2±0.00^c	1.6±0.24^b	6.8±0.20^e
STZ + 50 mg costus	5.8±0.37^e	4.2±0.37^d	4±0.00^e	7±0.54^e	4.2±0.37^d	1.4±0.24^b	26.6±0.92^g	5.8±0.37^f	2.2±0.20^c	2.2±0.20^c	10.2±0.58^g
STZ + 100mg costus	4.4±0.74^d	4.6±0.24^d	4±0.00^e	5.6±0.50^d	3.2±0.37^C	1.4±0.24^b	22.6±1.5	4.2±0.37	2±0.63^c	1.6±0.40^b	7.6±1.16
STZ +150 mg costus	2.2±0.48^b	3±0.44^C	2±0.00^C	4.2±0.48^C	2.4±0.24^C	1.8±0.2^b	15.8±0.96^d	2.6±0.24^c	1,80±0.58^b	1.2±0.37^b	5.6±1.16^d
STZ +50 mg nanocostus	1.2±0.20^b	0±0.00^a	0.4±0.24^a	0.2±0.20^a	1.2±0.20^b	1.2±0.20^b	4±0.44^b	1±0.00^a	0.6±0.24^a	0±0.00^a	1.6±0.2^a
STZ +100 mgnanocostus	2.6±0.40^C	0.4±0.24^a	1.2±0.20^b	1±0.0^b	2.8±0.20^c	2.2±0.20^c	10.2±0.37^c	1.6±0.24^b	1.2±0.20^b	0.6±0.24^a	3.4±0.24^b

Table 3: Mean percentages ± SE of chromosomal aberrations in rat bone marrow cells after treatment with STZ and/or costus or nanocostus. Small different superscript letters are differing significantly.