| Class |
Complication/Toxicity |
Incidence (%) |
Reference |
Management |
| Constitutional |
Fatigue |
28-52 |
22,69,71 |
Self Limiting
Steroid |
| |
Abdominal Pain/discomfort |
16-19 |
22,69,71 |
Self Limiting
Steroid
Analgesics |
| |
Nausea |
6-13 |
22,71 |
Steroid
Antiemetics |
| Hepatic/Tumor Vasculature |
Gastritis |
5 |
10 |
Analgesics
Antiemetics
Bismuth
Motility Agent
H2 blocker or PPI |
| |
Cholecystitis |
3
(1% requiring surgery),
case reports |
13-15 |
Observation
Cholecystectomy |
| |
Radiation Pneumonitis |
0-6 |
35,38 |
High dose steroids |
| Hepatic Parenchyma |
Biochemical Liver Toxicity: Grade III or higher
(ALP, AST, ALT, bilirubin) (transient) |
6-27 |
22,43,44 |
Self Limiting |
| |
Radiation Induced Liver Disease (RILD) or failure |
0-20 |
20,44,45,70 |
High dose steroids |
| |
Portal Hypertension; Fibrosis |
Case Reports |
13,19,72 |
Observational
TIPS |
| |
Biloma/abscess |
1 |
14 |
Observational
Drainage |
| |
Ascites |
11 (advanced liver disease) |
69 |
Drainage |
| |
Encephalopathy |
3 cases (more common after second treatment) |
44 |
Lactulose
Supportive |
| |
Hemobilia |
Single reported case |
44 |
|
| Systemic Toxicities |
Pancytopenia |
Case Report (likely due to free Yttrium-90 unbound to microsphere) |
73 |
Supportive |
|
