Group Age Histology Tumor size Hormone receptor status Margin status LN status ASTRO >/= 60 Invasive ductal or other favorablehistologies </= 2 cm ER+ Negative (at least 2 mm) pN0 (i-,i+) American Society of Breast Surgeons >/= 45 IDC or DCIS </= 3 cm NS Margin negative pN0 American Brachytherapy Society Task Group >/= 50 IDC </= 3 cm NS NS N0

Table 2: Guidelines for appropriate/suitable patients for APBI. IDC=Invasive Ductal Carcinoma; DCIS =Ductal Carcinoma in situ; NS=Not Specified; ER=Estrogen Receptor Positive.