Figure 3: Patient with malignant melanoma in the right thigh (surgically excised 1 month prior to PET/CT scan) and positive right inguinal SLNB (stage IIIA). Initial staging. FDG PET/CT study: axial and coronal sections of PET/CT, as well as Maximum Intensity Projection (MIP) of whole body (A1) and feet (A2) are shown. There is increased FDG uptake in right inguinal (a., A1., red arrow) and right thigh lymph nodes (b. A1., blue arrow) (SUVmax=5,9) consistent with lymph node metastases. Increased FDG uptake (SUVmax=4.6) is also noted in multiple subcutaneous nodules in the right thigh and right lower leg (c., d., A2., green arrows), consistent with metastatic subcutaneous deposits. Total hip arthroplasty (THA) bilaterally with subtle diffuse uptake of FDG. The yellow arrow on the MIP image of the feet points the blood pool activity within the popliteal vessels. Increased FDG uptake in the gastrointestinal track due to metformin medication is also noted (PET/CT department of the Biomedical Research Foundation of the Academy of Athens).