| Author |
No. of Patients |
CT during IMRT |
IMRT technique |
Results |
| |
|
|
|
Spinal cord (D2) |
Brain stem (D2) |
Parotid (Dmean) |
CTV (D95) |
| Lee et al. [9] |
10 |
Daily |
Not stated |
Not stated |
Not stated |
Increase in DIR plan by 3 Gy |
Not stated |
| O' Daniel et al. [10] |
11 |
Twice per week |
SIB |
Not significant |
Not stated |
Ipsilateral: Increase in DIR plan by 3 Gy (P = 0.026) Contralateral: Increase in DIR plan by 1 Gy (P=0.016) |
Not significant |
| Wu et al. [11] |
11 |
Six times weekly |
SIB |
*Not significant |
*Not significant |
Significant increased |
Not significant |
| Xivry et al. [12] |
10 |
Four times |
SIB |
Increase in DIR plan by 0.78 Gy |
Not stated |
Ipsilateral: Increase in DIR plan by 0.93 Gy Contralateral: Increase in DIR plan by 0.53 Gy |
Increase in DIR plan by 0.06 Gy |
| Castadot et al. [13] |
10 |
Four times |
Not stated |
Difference 0.9 Gy |
Not stated |
Increase in DIR plan by 0.8 Gy |
Not significant |
| Our study |
10 |
Once |
Two-step |
Not significant (P=0.32) |
Not significant (P=0.29) |
Ipsilateral: Increase in DIR plan by 3.2 Gy (P<0.01) Contralateral: Increase in DIR plan by 1.8 Gy (P < 0.05) |
Increase in DIR plan by 0.5 Gy (P<0.01) |
| *Wu et al. used dose to the maximum 1% of the volume of the spinal cord and brain stem. Abbreviations: CT: Computed Tomography; IMRT: Intensity-Modulated Radiotherapy; D2: dose to the maximum 2% of the volume, a representation of maximum dose; Dmean: mean dose; CTV: clinical target volume; D95: dose to the 95% of the volume; DIR: Deformable Image Registration; SIB: Simultaneous Integrated Boost |
