CAs in the study subjects. Data represents

Patient no.	Sex/age (Y)	Habits Smoker (S)/Non-smoker (NS)	Percentage of chromosomal aberrations
			Control	Duration oftreatment (dose in Gy)
			Prior to treatment	I Week	II Week	III Week	IV Week	V Week	VI Week
			(0 Gy)	(10 Gy)	(20 Gy)	(30 Gy)	(40 Gy)	(50 Gy)	(60 Gy)
P1	F/45	NS	0.75 ± 0.5	1.0 ± 0.5*	1.5 ± 1.0*	2.5 ± 1.7**	4.0 ± 2.1**	5.5 ± 2.3***	7.25 ± 2.6***
P2	M/46	NS	1.0 ± 0.3	1.5 ± 0.5*	2.0 ± 0.8*	2.75 ± 1.7**	4.25 ± 2.8**	6.0 ± 3.5**	8.5 ± 3.8***
P3	M/37	NS	0.75 ± 0.5	1.25 ± 0.5*	2.25 ± 1.8*	3.25 ± 1.8**	4.5 ± 1.7***	6.25 ± 2.6***	9.0 ± 4.2***
P4	F/56	NS	0.9 ± 0.2	1.0 ± 0.6*	2.5 ± 1.2*	3.5 ± 2.5**	4.75 ± 3.0**	6.5 ± 4.0**	9.5 ± 4.7***
P5	M/37	NS	1.25 ± 0.5	1.75 ± 0.9*	2.5 ± 1.7 *	3.5 ± 2.6 **	4.75 ± 3.0 **	7.75 ± 4.7 **	10.0 ± 5.5 ***
P6	M/62	S	1.0 ± 0.2	1.25 ± 0.9*	2.25 ± 1.2*	3.5 ± 2.3**	6.25 ± 3.4**	8.25 ± 5.9**	11.25 ± 6.8***
P7	M/42	S	1.25 ± 0.6	1.5 ± 1.2*	3.0 ± 1.4**	4.25 ± 3.2**	7.25 ± 3.4***	9.0 ± 5.0***	10.75 ± 5.9***
P8	M/69	S	1.5 ± 0.5	1.75 ± 0.9*	2.0 ± 1.8 *	3.75 ± 2.3 **	5.5 ± 3.0 **	9.0 ± 4.3 ***	11.25 ± 4.9 ***
P9	M/71	S	1.25 ± 0.5	1.75 ± 1.5*	3.25 ± 1.8**	4.0 ± 2.7**	6.0 ± 4.9**	8.75 ± 6.3**	11.75 ± 6.8***
P10	M/47	S	1.25 ± 0.2	2.0 ± 1.4*	2.75 ± 1.7*	3.75 ± 1.7**	5.75 ± 2.5***	8.25 ± 3.9***	10.5 ± 5.8***
Average values of NS (P1 to P5)			0.93 ± 0.20	1.35 ± 0.40*	2.20 ± 0.40*	3.15 ± 0.50 **	4.65 ± 0.60 **	6.50 ± 1.00 **	8.95 ± 1.20 ***
Average values of S (P6 to P10)			1.26 ± 0.10	1.60 ± 0.20 *	2.60 ± 0.50 *	3.80 ± 0.30**	5.95 ±0.90**	8.55 ± 0.90**	11.00 ± 0.60***
Average values of NS + S (P1 to P10)			1.09 ± 0.20	1.47 ± 0.30*	2.40 ± 0.50*	3.47 ± 0.50 **	5.30 ± 1.02**	7.52 ± 1.30**	09.97 ± 1.41***

Table 1: CAs in the study subjects. Data represents total CAs in peripheral blood lymphocytes of HNSCC patients before (0 Gy) and after various doses (10, 20, 30, 40, 50, and 60 Gy) of RT as a mean ± SD. Note: 1. Student’s t-test; shows statistically significant differences in total CAs at different doses compared with control values, *represent p<0.05, **represent p<0.01 and ***represent p<0.001. Note: 2. Two way ANOVA; Interindividual variation showed significant (Rows: p<0.001; F=17.56 and column: p<0.001; F=119.83) difference by two way ANOVA. The nullhypothesis [H_o] that “there are no inter and intra individual differences” was tested at 95%, 99%, 99.9% confidence intervals. Abbreviations: P: Patient; S: Smoker; NS: Non-Smoker; M: Male; F: Female; RT: Radiotherapy; Y: Year and Gy: Gray.