| QUADAS criteria |
| References |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
| Durie et al. [18] |
Y |
Y |
Y |
N |
Y |
Y |
Y |
Y |
N |
Y |
Y |
Y |
Y |
Y |
| Bredella et al. [19] |
Y |
Y |
Y |
Y |
Y |
N |
Y |
N |
N |
Y |
Y |
Y |
Y |
Y |
| Zamagni et al. [21] |
U |
Y |
Y |
U |
U |
Y |
Y |
N |
Y |
U |
Y |
Y |
Y |
Y |
| Nanni et al. [20] |
U |
Y |
Y |
U |
Y |
N |
Y |
N |
Y |
U |
Y |
Y |
Y |
Y |
| Kim et al. [22] |
Y |
Y |
Y |
Y |
Y |
U |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
| Nanni et al. [23] |
Y |
Y |
Y |
U |
Y |
Y |
Y |
N |
N |
U |
Y |
Y |
Y |
U |
| Elliott et al.[24] |
Y |
Y |
N |
Y |
Y |
U |
Y |
N |
N |
Y |
N |
Y |
Y |
Y |
| Sager et al. [25] |
Y |
Y |
Y |
Y |
U |
N |
Y |
Y |
Y |
U |
Y |
Y |
Y |
U |
| Ho et al. [26] |
Y |
Y |
Y |
Y |
Y |
N |
Y |
Y |
Y |
Y |
Y |
Y |
Y |
U |
| Park et al. [27] |
Y |
Y |
Y |
U |
Y |
Y |
Y |
N |
N |
Y |
Y |
Y |
Y |
Y |
| Okasaki et al. [28] |
U |
Y |
Y |
Y |
N |
U |
Y |
N |
Y |
N |
N |
Y |
Y |
U |
| 1. Was the spectrum of patients representative of the patients who will receive the test in practice? |
| 2. Were the selection criteria clearly described? |
| 3. Is the reference standard likely to correctly classify the target condition? |
| 4. Is the time period between the reference standard and the index test short enough to be reasonably sure that the target condition did not change between the two tests? |
| 5. Did the whole sample or a random selection of the sample receive verification using a reference standard of diagnosis? |
| 6. Did patients receive the same reference standard regardless of the index test result? |
| 7. Was the reference standard independent of the index test (i.e., the index test did not form part of the reference standard)? |
| 8. Was the execution of the index test described in sufficient detail to permit replication of the test? |
| 9. Was the execution of the reference standard described in sufficient detail to permit its replication? |
| 10. Were the index test results interpreted without knowledge of the results of the reference standard? |
| 11. Were the reference standard results interpreted without knowledge of the results of the index test? |
| 12. Were the same clinical data available when the test results were interpreted as would be available when the test is used in practice? |
| 13. Were uninterpretable/intermediate test results reported? |
| 14. Were withdrawals from the study explained? |
| N:No; U:Unclear; Y:Yes. |
