Author (ref) No. of pts IMRT platform Median volume  Median dose Median follow-up  PFS/local control Overall survival Late toxicity
Uy (23) 40 Peacock-NOMOS 20.2 cc 50.4 Gy 30 months 93% (5-year) 89% (5-year) 5%
Pirzkall (24) 20 KonRad, Siemens
CORVUS-NOMOS
108 cc 57 Gy 36 months 100% (imaging)
95% (clinical)
NR 0
Sajja (25) 35 Peacock-NOMOS NR 50.4 Gy 19.1 months 97% (3-year) NR 0
Milker-Zabel (26) 94 KonRad, Siemens 81.4 cc 57.6 Gy 52 months 95% (5-year) 97% (5-year) 4%
Combs (27)  12 Helical Tomotherapy NR 58 Gy 12 months 4/12 pts (all grade II-III)  progressed 100% 8%
Luis (28) 28 Helical Tomotherapy 43.3 cc 51.7Gy 7.5 months 100% (imaging) 100% NR
Present study  19 Helical Tomotherapy 87.8 cc 54 Gy 32 months 89.2% (5-year) 100% (5-year) 5%
Pts=patients; PFS=progression-free survival; NR=not reported
Table 4: Prospective clinical studies of intensity-modulated radiation therapy (IMRT) in meningiomas.