Drug /
Parameters |
Cmax
(mg/L) |
t1/2
(min) |
MRT0-∞
(min) |
Vss
(L/kg) |
AUC0-∞
(g.min/L) |
CL
(L/h/kg) |
Lip 175 |
31.6 ± |
127 ± |
184 ± |
0.21 ± |
5.7 ± |
1.2 ± |
| |
6.3 |
25 |
35 |
0.04 |
1.2 |
0.3 |
|
Lip 400 |
17.3 ± |
26.5 ± |
38.3 ± |
0.26 ± |
0.63 ± |
7.0 ± |
| |
5.4 |
7.9 |
11.5 |
0.07 |
0.14 |
1.6 |
|
Free |
172 ± |
15.2 ± |
25.5 ± |
0.60 ± |
4.1 ± |
24.4 ± |
|
Drug |
37 |
9.8 |
9.8 |
0.16 |
0.5 |
2.5 |
aDogs (n= 4-5) received small size liposomes (Lip 175, 6.5 mg Sb/kg body weight),
medium size liposomes (Lip 400, 4.2 mg Sb/kg) or free drug (100 mg Sb/kg).
Blood samples were collected at different time intervals for determination of Sb
by graphite furnace atomic absorption spectroscopy. Pharmacokinetic parameters
were determined using Rstrip 4.03 computer program. Cmax, maximum blood
concentration of Sb; t1/2, half- life of blood elimination of Sb; MRT0-∞, mean
residence time of Sb projected to infinity; Vss, volume of distribution at steady
state; AUC0-∞, area under the blood concentration–time curve projected to infinity;
CL, total body clearance of Sb. |
