Tissue

AUC[0-24h]

AUC[0-]

AUMC[0-24h]

MRT

STV-DS

Blood

23.938

28.811

32.901

2.055

Lungs

122.505

138.382

850.72

10.251

Liver

301.945

344.719

2205.08

10.817

Spleen

35.133

35.136

136.99

3.901

Kidneys

200.60

219.674

1369.38

9.095

Heart

22.338

22.342

105.612

4.473

NP

Blood

34.566

39.165

76.103

3.369

Lungs

154.955

168.983

1009.84

8.674

Liver

335.555

374.968

2408.54

9.944

Spleen

196.605

205.711

1214.16

7.324

Kidneys

102.81

110.742

656.12

8.153

Heart

62.88

74.196

437.62

11.234

DNP

Blood

28.985

34.355

72.892

4.128

Lungs

172.45

183.882

1089.42

7.943

Liver

570.62

702.674

4783.7

13.773

Spleen

312.09

381.64

2672.26

13.189

Kidneys

107.58

117.167

730.24

8.799

Heart

62.74

72.763

378.64

9.877

PNP

Blood

20.829

23.764

25.085

1.717

Lungs

193.415

200.557

1194.52

7.067

Liver

540.95

696.951

4774.02

15.214

Spleen

311.24

352.997

2303.2

10.640

Kidneys

59.973

59.975

273.972

4.569

Heart

55.838

55.841

239.632

4.293

BNP

Blood

27.529

31.829

62.850

3.619

Lungs

213.47

230.952

1432.2

8.676

Liver

425.165

465.45

3056.72

9.321

Spleen

287.61

335.433

2253.14

11.661

Kidneys

69.268

69.271

296.112

4.276

Heart

57.01

69.849

345.90

11.772

Table 2: Pharmacokinetic parameters of stavudine NP and SM-NP in comparison with STV-DS.