| Name |
Goal |
Lower Limit |
Upper Limit |
Importance |
| A:PLGA |
Is in Traget |
100 mg |
300 mg |
3 |
| B:PVA |
Is in range |
0.5 % |
3% |
3 |
| C:Speed |
Is in range |
5000 rpm |
20000 rpm |
3 |
| Particle Size |
In range |
110 nm |
750 nm |
3 |
| Entrapment Efficiency |
Maximise |
31 % |
70 % |
3 |
|
| Solution No. |
PLGA |
PVA |
Speed |
Particle Size |
Entrapment Efficiency |
Desirability |
| 1 |
299.99 |
2.95 |
19999.98 |
750 |
69.33 |
0.98 |
| 2 |
260 |
2.75 |
18000 |
640 |
71.69 |
0.98 |
| 3 |
296.18 |
3.00 |
19729.60 |
750 |
68.84 |
0.97 |
| 4 |
300.00 |
2.90 |
19999.95 |
747.74 |
69.17 |
0.97 |
| 5 |
297.30 |
3.00 |
19999.98 |
747.43 |
69.14 |
0.97 |
| 6 |
300.00 |
2.84 |
19999.92 |
744.93 |
68.99 |
0.97 |
| 7 |
300.00 |
2.86 |
19782.98 |
749.99 |
68.92 |
0.97 |
| 8 |
295.21 |
3.00 |
19994.14 |
743.62 |
68.87 |
0.97 |
| 9 |
300.00 |
2.84 |
19738.96 |
749.99 |
68.84 |
0.97 |
| 10 |
245 |
1.26 |
14999.69 |
426 |
75.69 |
0.98 |
|
| Table 4b: Set parameters and some of the suggested solutions of PTX-PLGA nanoparticles. |
