S. No R1 R2 R3 R4 R5 MICa MICb MICc MICd 1 F H H H H 4.798 4.795 4.494 4.494 2 H CF3 H H H 4.795 4.494 4.494 4.494 3* H H F H H 4.494 4.193 4.795 4.795 4 H H Cl H H 4.193 4.494 4.494 4.795 5 H H I H H 4.193 3.892 4.795 4.795 6 H H CH3 H H 4.494 3.290 4.795 4.494 7 F H F H H 4.795 4.795 4.795 4.795 8* Cl H Cl H H 4.193 4.795 4.494 4.494 9 H CF3 H CF3 H 5.698 5.096 5.698 5.698 10 H H H H 3.892 3.892 3.892 3.892 11 H H H H 3.892 4.795 3.591 4.795 12* H H H H 4.494 3.892 3.892 4.795 13 H H H H 3.892 3.892 3.892 4.795 14 H H H H 4.193 4.795 3.892 4.795 15 H H H H 3.892 3.591 3.591 4.494 16 F H H H 3, 4-2 Cl 4.193 3.892 4.494 4.494 17* H CF3 H H 2, 4-2 Cl 4.494 4.494 4.795 4.795 18 H H F H 2, 4-2 Cl 4.494 4.795 3.892 4.494 19 H H CH3 H 2-Cl 4.193 3.892 4.494 4.494 20 H H CH3 H 3-Cl 4.494 3.892 4.494 4.494 21* H H CH3 H 4-Cl 4.494 3.892 4.494 4.795 22 H H CH3 H 4-NO2 4.494 3.892 4.795 3.892 23 H H CH3 H 2, 4-2F 4.795 4.795 3.892 4.494 24 H H CH3 H 2, 4-2 Cl 4.193 3.892 4.494 4.795 25 H H CH3 H 3, 4-2 Cl 4.494 4.795 4.795 3.892 26 F H F H 2, 4-2 Cl 4.193 4.795 4.494 3.892 27 Cl H Cl H 2, 4-2F 4.193 3.892 4.795 3.892 28* H CF3 H CF3 2, 4-2F 5.096 5.096 4.795 4.795 29 H CF3 H CF3 2, 4-2 Cl 4.193 3.892 4.795 4.795 30 H H H H 4.193 4.795 3.892 4.795 31 H H H H 5.096 5.096 4.494 5.096 32* H H H H 4.494 3.892 3.892 4.795 33 H H H H 3.892 3.892 3.892 4.795 34 H H H H 4.193 3.892 3.892 4.494 * Test compounds aStaphylococcus aureus;  bMicrococcus luteus;  cEscherichia coli; dCandida albicans

Table 1: Structures and antimicrobial activities of benzimidazole type of Fluconazole analogues.