Com S. aureus Model-1 M. luteus Model-2 E. coli-model-3 C. albicans-model-4 Pred. Res. Pred. Res. Pred. Res. Pred. Res. 1 4.326 0.472 4.741 0.054 4.461 0.033 4.513 -0.019 2 4. 852 -0.057 4.514 -0.02 4.474 0.02 4.466 0.028 3 4.374 0.12 4.183 0.01 4.813 -0.018 4.813 -0.018 4 4.087 0.106 4. 462 0.032 4.487 0.007 4.687 0.108 5 4.329 -0.136 3.956 -0.064 4.831 -0.036 4.771 0.024 6 4.299 0.195 3.216 0.074 4.708 0.087 4.342 0.152 7 4.582 0.213 4.769 0.026 4.921 -0.126 4.828 -0.033 8 4.046 0.147 4.706 0.089 4.528 -0.034 4.467 0.027 9 5.825 -0.127 5.149 -0.053 5.645 0.053 5.645 0.053 10 3.625 0.267 3.791 0.101 3.759 0.133 3.936 -0.044 11 3.941 -0.049 4.626 0.169 3.684 -0.093 4.808 -0.013 12 4.174 0.32 3.886 0.006 3.929 -0.037 4.824 -0.029 13 3.661 0.231 3.933 -0.041 3.646 0.246 4.737 0.058 14 4.083 0.11 4.915 -0.12 3.788 0.104 4.723 0.072 15 3.738 0.154 3.648 -0.057 3.589 0.002 4.381 0.113 16 4.365 -0.172 3.691 0.201 4.364 0.13 4.469 0.025 17 4.364 0.13 4.431 0.063 4.717 0.078 4.837 -0.042 18 4.593 -0.099 4.631 0.164 3.911 -0.019 4.763 -0.269 19 4.013 0.18 3.712 0.18 4.562 -0.068 4.391 0.103 20 4.249 0.245 3.926 -0.034 4.359 0.135 4.374 0.12 21 4.383 0.111 3.819 0.073 4.536 -0.042 4.831 -0.036 22 4.413 0.081 3.708 0.184 4.872 -0.077 3.866 0.026 23 4.681 0.114 4.816 -0.021 3.767 0.125 4.478 0.016 24 4.333 -0.14 3.967 -0.075 4.379 0.115 4.683 0.112 25 4.438 0.056 4.671 0.124 4.882 -0.087 3.922 -0.03 26 4.296 -0.103 4.914 -0.119 4.339 0.155 3.851 0.041 27 4.037 0.156 3.799 0.093 4.813 -0.018 3.830 0.062 28 5.333 -0.237 5.108 -0.012 4.731 0.064 4.787 0.008 29 4.358 -0.165 3.935 -0.043 4.769 0.026 4.752 0.043 30 3. 992 0.201 4.739 0.056 3.862 0.03 4.806 -0.011 31 4.964 0.132 5.018 0.078 4.516 -0.022 5.186 -0.09 32 4.281 0.213 3.909 -0.017 3.824 0.068 4.653 0.142 33 3. 658 0.234 3.834 0.058 3. 873 0.019 4.769 0.026 34 4.362 -0.169 3.912 -0.02 3.916 -0.024 4.353 0.141

Table 3: Predicted activities according to 2D QSAR models results of benzimidazole type of Fluconazole analogues.