Figure 5: Histopathological findings. (a) Normal cortex, (b) now tumor shows pleomorphic astrocytes, (c) nuclear pleomorphism, with mitotic activity center necrosis around the vessels. In group (3a) are observed: (d) dense deposition of the nanoparticles and (f) tumor around those particles. In group (3b) are evidenced: (g) abundant macrophages immersed in nanoparticles and (h) the peritumoral area with edema and gliosis. In group (3c) (i) the tumoral areas, that the scarce neoplastic astrocytes are immersed in edema and vessels, in other areas are presented polimorfonuclear leucocytes with necrosis and in (j) we show inflammatory cells and gliosis. 3a- tumor model used with Cu(NH4)2 Cl4 /F-TiO2. 3b-Tumor model used with Cu(Oac)2/F-TiO2 .3c-Tumor model used with Cu(acac)2/F-TiO2.