Histological Findings 1 2 3a 3b 3c
Tumoral necrosis 3 1 1 N N
Tumoral inflammation 2 1 2 3 1
Macrophages  presence 1 1 2 3 1
Lymphocytes presence 1 1 2 3 1
Vessels presence 2 1 2 2 1
Hemorrhage 2 2 1 N N
Mitosis index 10 7 5 3 1
Nanoparticles N 3 2 1 1
Peritumoral necrosis N 1 2 1 N
PeritumoraI inflammation N 1 3 2 N
Peritumoral macrophages N 1 2 3 1
Lymphocytes 1 1 2 2 1
Gliosis 1 1 3 3 1
Peritumoral hemorrhage N 2 N N N
Nanoparticles N 1 2 1 1
Neoplastic cells N 1 2 N N
Table 2: Histopathological findings in the GBM tumor and peritumoral boundary. 1-C6 cells, 2-tumor model used only with TiO2, 3a,3b,3c- tumor model used with different copper complexes supported in TiO2.