S.No. |
Batch code |
PLGA (mg) |
Acetone (ml) |
Lomustine (mg) |
Stabilizer solution(ml) |
PS(nm)
(Mean ± SD*) |
PDI
(Mean±SD*) |
ZP(mV)
(Mean ± SD*) |
DC(mg) |
% EE
(Mean ± SD*) |
1. |
PD1 |
100mg PDLG5002 |
10 |
1 |
1:5, 1%w/v PVA |
296.9±12.2 |
0.135±0.013 |
-0.964 ±0.029 |
0.87 |
87%±0.76 |
2. |
PD2 |
200mg PDLG5002 |
10 |
1 |
1:5, 1%w/v PVA |
316.2±13.4 |
0.128±0.009 |
-2.09 ±0.063 |
0.92 |
92.4%±0.70 |
3. |
PD3 |
300mg PDLG5002 |
10 |
1 |
1:5, 1%w/v PVA |
335.8±10.6 |
0.122±0.016 |
-8.14 ±0.076 |
0.98 |
98.1% ± 0.67 |
4. |
PD4 |
100mg PDLG7502 |
10 |
1 |
1:5, 1%w/v PVA |
318.9±14.3 |
0.136±0.012 |
-2.06 ±0.012 |
0.88 |
88.3% ± 0.81 |
5. |
PD5 |
200mg PDLG7502 |
10 |
1 |
1:5, 1%w/v PVA |
344.5±13.6 |
0.127±0.011 |
-1.29 ±0.034 |
0.93 |
93% ± 0.66 |
6. |
PD6 |
300mg PDLG7502 |
10 |
1 |
1:5, 1%w/v PVA |
370.3±11.4 |
0.138±0.006 |
-0.61 ±0.012 |
0.98 |
98.6% ± 1.02 |
7. |
PD7 |
100mg PDLG5002 |
20 |
1 |
1:5, 1%w/v PVA |
227.3±13.5 |
0.131±0.016 |
-0.471 ±0.008 |
0.85 |
85% ± 0.86 |
8. |
PD8 |
100mg PDLG5002 |
30 |
1 |
1:5, 1%w/v PVA |
198.5±11.4 |
0.110±0.014 |
-0.238 ±0.017 |
0.80 |
80.3% ± 0.84 |
9. |
PD9 |
100mg PDLG5002 |
10 |
5 |
1:5, 1%w/v PVA |
304.2±12.5 |
0.117±0.011 |
-7.78 ±0.121 |
4.8 |
96% ± 0.82 |
10. |
PD10 |
100mg PDLG5002 |
10 |
10 |
1:5, 1%w/v PVA |
307.8±11.2 |
0.124±0.008 |
-8.2 ±0.018 |
9.95 |
99.5% ± 0.75 |
11. |
PD11 |
100mg PDLG5002 |
10 |
1 |
1:5, 3%w/v PVA |
334.6±10.7 |
0.156±0.007 |
-4.44 ±0.098 |
0.88 |
88% ± 0.63 |
12. |
PD12 |
100mg PDLG5002 |
10 |
1 |
1:5, 1%w/v Pluronic F68 |
177.2 ±14.1 |
0.135 ±0.018 |
-4.3 ±0.26 |
0.81 |
81% ± 0.85 |
13. |
PD13 |
100mg PDLG5002 |
10 |
1 |
1:5, 3%w/v Pluronic F68 |
167.9±11.5 |
0.143±0.011 |
-5.1±0.312 |
0.79 |
79% ± 0.68 |
14. |
PD14 |
100mg PDLG5002 |
10 |
1 |
1:10, 1%w/v PVA |
298.4±10.1 |
0.192±0.007 |
-6.63±0.148 |
0.86 |
88% ± 0.65 |
15. |
PD15 |
100mg PDLG5002 |
10 |
1 |
1:10,1%w/v Pluronic F68 |
197.9±13.2 |
0.278±0.007 |
-5.8±0.207 |
0.85 |
85% ± 0.9 |
L/G ratio of: For PDLG 5002 is 50:50; For PDLG 7502 is 75:25. n=3, SD* = Standard deviation, PS: Particle size, PDI: Polydispersity index,
ZP: Zeta potential, DC: Drug content, EE: Entrapment efficiency. |