S.No Batch code Initial DC(%w/w) (mean± SD*) Drug content (%w/w) After one month After two months After 3 months At25°C/60%RH (mean ± SD*) At45°C/70%RH (mean± SD*) At 25°C/60%RH (mean ± SD*) At 45°C/70%RH (mean± SD*) At 25°C/60%RH (mean ± SD*) At45°C/70%RH (mean± SD*) 1. PD1 90±0.03 90±0.01 89±0.03 89.9±0.05 88.6±0.01 89.9±0.02 87.9±0.06 2. PD4 90.6±0.05 90.6±0.04 90.3±0.04 90.6±0.02 90.0±0.04 90.5±0.03 89.8±0.02 3. PD13 97± 0.05 97±0.02 96.8±0.03 97±0.04 96.7±0.05 97±0.03 96.5±0.04 *n=3 SD: Standard deviation, DC: Drug Content

Table 2: Drug content of nanoparticles stored at different temperatures for 3 months.