Product No. of Bleeds Dosage Median (Range) No. of Doses Median (Range) Type 1* Intravenous desmopressin 29 0.3 (0.3–2.0) μg/kg 1 (1–9) Intranasal desmopressin 4 300 (300–300) μg/kg 1 (1–3) VWF/FVIII concentrates 4 40 (30–50) IU/kg 8 (8–8) Type 2† Intravenous desmopressin 21 0.3 (0.3–1) μg/kg 2.0 (1–6) Intranasal desmopressin 4 150 (150–300) μg/kg 2.5 (2–3) VWF/FVIII concentrates 28 50 (10–70) IU/kg 4.0 (1–15) Type 3‡ Intravenous desmopressin 0 Not reported Not reported Intranasal desmopressin 0 — — VWF/FVIII concentrates 37 50 (10–70) IU/kg 6.0 (1–30) FVIII: Factor VIII; VWF: Von Willebrand Factor. Note: VWF/FVIII concentrates include Humate-P®, Alphanate® SD/HT, and Koate®- DVI. *Dosing data not reported/available for 3 events treated with DDAVP and 1 event treated with VWF/FVIII concentrates; †Dosing data not reported/available for 3 events treated with DDAVP and 7 events treated with VWF/FVIII concentrates; ‡ Dosing data not reported/available for 2 events treated with DDAVP and 5 events treated with VWF/FVIII concentrates.

Table 5: Summary of Desmopressin and VWF/FVIII Concentrate Dosing to Treat Bleeding Events by VWD Type