| Authors |
Mutation (polymorphisms) tested |
Population findings |
Results |
| Kubisz et al. [18] |
GPIIIa PIA A1/A2 |
9 patients with SPS (4M /5F; 2TI/ 6TII/ 1TIII); whites |
No clear relation between SPS and SNP |
| Kubisz et al. [19] |
Gas6 c.834 +7G > A |
128 patients with SPS (42M/ 86F; 35TI/ 91TII/ 2TIII); 137 controls; withes |
No significant differences between SPS and control group; G allele more prevalent in SPS Type II |
| Ruiz-Argüelles et al. [21] |
GPIIIa PIA A1/A2 |
95 patients with SPS (43M/ 52F; 61TI/ 6TII/ 28TIII); 127 controls; Mexican mestizo |
No significant differences between SPS and control group |
| Kubisz et al. [22] |
6 GP6 SNPs (rs1654410, rs1671153, rs1654419, rs11669150, rs12610286 and rs1654431) |
71 patients with SPS (stroke; 24M/ 47F; 17TI/ 52TII/ 2TIII) 77 controls; whites |
No significant differences between SPS and control group; SNP rs12610286, haplotype TTGTGA significant more frequent in SPS Type I compared with controls |
| Sokol et al. [23] |
27 patients with SPS (fetal loss; 27F; 7TI/ 20TII); 42 controls; whites |
3 SNPs significantly more frequent (rs1671153, rs1654419, rs1613662) in SPS group; significant higher occurrence of 2 haplotypes (CTGAG, CGATAG) |
| Kotuličová et al. [24] |
77 patients with SPS (VTE; 22TI/ 54TII/ ); 77 controls; whites |
2 SNPs (rs1613662, rs1654419) significant more frequent in SPS group; 2 SNPs (rs1671153, rs1654419) significantly more frequent in Type II compared with controls |
| Kubisz et al. (Peter Kubisz, MD, DSc, Unpublished data March 2013) |
4 Gas6 SNPs (rs7400002, rs1803628, rs8191974, rs9550270), 2 PEAR1 SNPs (rs12041331, rs12566888), 2 MRVI1 SNPs (rs7940646, rs187445) |
23 patients with SPS (fetal loss 23, W; 23, TIII); 42 controls; whites |
1 GAS6 SNP (rs7400002) and 1 PEAR1 SNP (rs12566888) significantly more frequent in SPS group |
GP: Glycoprotein; M: Men; SNP: Single Nucleotide Polymorphism; SPS: Sticky Platelet Syndrome; T: Type; VTE: Venous Thromboembolism; W: Women; TI: Hyperaggregability
to ADP and EPI; TII: Hyperaggregability to EPI alone; TIII: Hyperaggregability to ADP alone