| EBNA |
Relevant functions |
Examples of major interactions |
Evidence for role in cell transformation |
References |
| EBNA-1 |
Important for the maintenance of viral episomes, viral DNA replication, and transcriptional activation of latent EBV genomes; implicated in cell immortalization and transformation; implicated in immune evasion. |
HAUSP (USP7), Karyopherins 2 α and β; TAP/p32 |
Yes |
[87-93] |
| EBNA-2 |
Activation of viral and cellular promoters |
PU.1; CBF1/ RBP-J kappa |
Yes |
[94-97] |
| EBNA-3A (EBNA-3) |
Repression of the CBF1/RBP-J kappa dependent transcription |
CBF1/RBP-J kappa; RBP-2N |
Yes |
[98, 101] |
| EBNA-3B (EBNA-4) |
- |
CBF1/RBP-J kappa; RBP-2N |
No |
[101]. |
| EBNA-LP (EBNA-5) |
Co-activation of EBNA-2-dependent transcription |
Hsp27; Hsp70 (Hsp72); Hsc70 (Hsp73); HAX-1; HA95; alpha & beta tubulins; prolyl-4-hydroxylase alpha-1 subunit; p14ARF; Fte-1/S3a |
Yes |
[102-104] |
| EBNA-3C (EBNA-6) |
Repression of the CBF1/RBP-J kappa dependent transcription |
CBF1/RBP-J kappa; RBP-2N |
Yes |
[99-101] |
CBF1: Centromere Binding Factor 1; HAUSP: Herpes Virus-Associated Ubiquitin-Specific Protease (USP7); HAX-1: HCLS1-Associated Protein X-1; HSP: Heath Shock
Proteins; RBP: Recombining Binding Protein Suppressor of Hairless; RBP-2N: Recombination Signal Sequence-Binding protein 2N; TAP, Transporrter Associated with
Antigen Processing