| LMP |
Relevant functions |
Examples of major interactions |
Evidence for role in oncogenesis |
References |
| LMP-1 |
Constitutively activated receptor functionally homologous to CD40 / mimics CD40 signaling.
Activates the NFkB, JNK kinase, JAK/STAT, MAPK and PKC pathways.
Up-regulates anti-apoptotic proteins, including A20 and BCL2.
Induces cell adhesion and immune regulatory membrane proteins.
Inhibits DNA repair and induces micronuclei formation, chromosomal aberrations, and genomic instability. |
RAF 1,2,3,
TRADD
BRAM 1
LMP-2A |
Yes (anti-apoptotic effect; survival of lymphoma cells; tumors in transgenic animals) |
[105-111] |
| LMP-2A |
Interacts with Src- and Syk-families of tyrosine kinases.
Activates PI3 kinase and the downstream phosphorylation of PKB.
Mimics a BCR-like activation signal / provides B cells with survival signals in the absence of normal BCR signaling.
Blocks lytic cycle / maintains viral latency.
Blocks BCR activation.
Induces epithelial cell mobility and invasion.
Promotes lymphoma cell survival via TRAF2 regulation of NF-κB. |
Src-family tyrosine kinases (Src, Lyn, Lck)
Syk-family tyrosine kinases
(Syk, ZAP-70)
AIP4/Nedd4 |
Yes (survival of B-cells and lymphoma cells; cell migration and invasion) |
[112-118] |
| LMP-2B |
Modulates LMP-2A function |
LMP-2A |
No |
AIP4: Atrophin-1-Interacting Protein 4 (Nedd4-Like E3 Ubiquitin Ligase); BCR: B-Cell Receptor; BRAM: BMP Receptor Associated Molecule; JAK: Janus Kinase; JNK: CJun
N-Terminal Kinases; LMP: Epstein Barr Virus-Encoded Latent Membrane Protein; MAP: Mitogen-Activated Protein Kinase; NEDD4: Neural Precursor Cell Expressed
Developmentally Down-Regulated Protein 4 (E3 Ubiquitin Ligase); Nfκb: Nuclear Factor κB; RAF: Rapidly Accelerated Fibrosarcoma Kinases; PKB: Protein Kinase B:Also
Known As Akt; Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein; Src: Short For “Sarcoma” (Tyrosine Kinase); Syk: Spleen Tyrosine Kinase
(Member Of The Syk Family Tyrosine Kinase); TRAF: TNF Receptor Associated Factor; ZAP-70: Zeta-Chain-Associated Protein Kinase 70