Total AML cases High BMI1 expression  (≥4.40) (n=51) Low BMI1 expression (<4.40) (n=49) P Age (years) 45.5 (19-60) 44 (19-60) 49 (19-59) 0.467 Sex Males 53 (53.0%) 25 (49.0%) 22 (44.9%) 0.879 females 47 (47.0%) 29 (56.9%) 24 (49.0%) WBCs (x109/l) 28.9 (2.7-210.0) 28.5 (2.7-210.0) 31 (3.7-181.0) 0.519 Hemoglobin concentration (g/dl) 8.2 (3.4-11.9) 8.2 (3.4-11.9) 8.3 (3.4-11.4) 0.799 Platelets (x109/l) 40.0 (5.0-675.0) 41 (7.0-649) 40 (5.0-675.0) 0.611 BM Blasts (%) 66.5 (25.0-99.0) 80 (33.0-99.0) 46 (25.0-95.0) <0.001 LDH (u/L) 745.5 (198.0-4362.0) 765 (216.0-4115.0) 698 (198.0-4362) 0.981 FAB M0 2 (2.0%) 1 (2.0%) 1 (2.0%) 0.781 M1 14 (14.0%) 7 (13.7%) 7 (14.3%) M2 28 (28.0%) 13 (25.5%) 15 (30.6%) M4 31 (31.0%) 18 (35.3%) 13 (26.5%) M5 18 (18.0%) 12 (23.5%) 6 (12.2%) M6 7 (7.0%) 3 (5.9%) 4 (8.2%) Clinical outcome CR 71 (71.0%) 43 (84.3%) 28 (57.1%) 0.120 RD 13 (13.0%) 5 (9.8%) 8 (16.3%) ID 16 (16.0%) 6 (11.8%) 10 (20.4%) Alive 59 (59.0%) 33 (64.7%) 26 (53.1%) 0.642 Died 41 (41.0%) 21 (41.2%) 20 (40.8%)

Age, WBC, hemoglobin concentration, platelet count, BM blasts and LDH are expressed in median and range. Sex, FAB, clinical outcome, alive and died are expressed in number and percentage. WBC: White Blood Cells; BM: Bone Marrow; LDH: Lactate Dehydrogenase Concentration; CR:Complete Remission; RD: Refractory Disease; ID: Induction Death

Table 2: Demographic, laboratory and clinical characteristics in AML cases according to BMI1 expression.